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How effective are antidepressants?
5HT and other matters
Platelet transport and receptor sites in depressive illness
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abnormalities action activity addiction adrenoceptors affective disorders agonists alcohol Alzheimer's disease amine amitriptyline amphetamine animals antagonist antidepressant treatment antipsychotic anxiety anxiolytic Arch arousal behaviour benzodiazepine benzodiazepine receptors binding biochemical brain caffeine cent central cerebral changes choline cholinergic chronic clinical cognitive controls Coppen correlated cortex cortical d-amph D2 receptors decreased deficits depressed patients depressive illness diazepam diazepines dopamine receptors dopaminergic doses drinking drugs effects evidence forebrain frontal function GABA genetic imipramine impairment increased induced inhibition inhibitors interaction Iversen lesions levels ligand limbic lithium mechanisms memory metabolism mianserin monoamine neurochemical neuroleptic neurones neurotransmitter nicotine nitrazepam noradrenaline normal nucleus onset Parkinson's disease Perry Pharmac Pharmacokinetics pharmacological physostigmine placebo plasma platelet potential Psychiat Psychol Psychopharmacology psychosis psychotropic rats recent reduced reported response reuptake Rossor schizophrenia Schulsinger serotonin sexual significant smoking specific stimulant studies suggested symptoms therapeutic therapy tion tricyclic antidepressants uptake ventricular withdrawal