Prostate Cancer: Biology, Genetics, and the New Therapeutics

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Springer Science & Business Media, Nov 10, 2007 - Medical - 530 pages
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Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.
 

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Contents

Xenograft Models of Human Prostate Cancer
3
The Pathology of Human Prostatic Atrophy and Inflammation
33
Tissue Microarrays in Prostate Cancer Research
49
Prostate Cancer Stem Cells
63
CancerHost Interactions A Paradigm Shift Brings New Understanding and New Opportunities
73
Androgen Receptor Function in Prostate Cancer Progression
87
7 Hedgehog Signaling in Development and Cancer
107
Cholesterol Cell Signaling and Prostate Cancer
119
Somatic Alterations in Prostate Cancer Progression
269
Linkage Studies of Prostate Cancer Families to Identify Susceptibility Genes
285
Somatic DNA Methylation Changes and Prostatic Carcinogenesis
301
Telomeres Telomerase Chromosome Stability and Prostate Cancer
317
Therapeutics
353
Racial Differences in Prostate Cancer Mortality
355
Radiotherapy for the Treatment of Locally Advanced Prostate Cancer
377
Recombinant Antibody Candidates for Treatment of Prostate Cancer
397

Gene Therapy for Advanced Prostate Cancer
139
Role of Transforming Growth Factorβ in Immunotherapy of Prostate Cancer
165
Biology and Therapeutic Basis of Prostate Cancer Bone Metastasis
175
Molecular Imaging Noninvasive Strategies to Visualize Gene Expression in Living Subjects
193
Quantum Dot Nanotechnology for Prostate Cancer Research
231
Genetics
245
Expression Profiling of Prostate Cancer Progression
247
Differentiation Agents and Epigenomic Therapies An Overview and Potential Use for Prostate Cancer
411
TaxaneBased Chemotherapy for Prostate Cancer
445
CoTargeting Therapeutics for Hormone Refractory Prostate Cancer
463
Intercellular Targets of Prostate Cancer
475
Novel and Efficient Translational Clinical Trial Designs in Advanced Prostate Cancer
487
Index
497
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