Pathogenicity of Human Herpesviruses Due to Specific Pathogenicity Genes
Yechiel Becker, Gholamreza Darai
Springer-Verlag, Jan 1, 1994 - Herpesvirus diseases - 387 pages
The questions of how the pathogenic human herpesviruses cause diseases, and what should be done to prevent infection and disease have prompted scientific interest in the molecular basis of the functions of all human herpesvirus genes in various tissues and organs of the infected host. This volume compiles the knowledge on the pathogenicity genes of herpes simplex virus types 1 and 2, the ones which have been most actively investigated at the molecular level. It adds to the understanding of herpesvirus gene involvement in diseases and shows the potential of this knowledge for planning new strategies for the development of vaccines in the future. The book will be of great help to physicians and to scientists concerned with the involvement of herpesviruses in aggravating patients' conditions, leading to a life threatening infection.
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Entry of Herpes Simplex Virus Type 1 into CellsEarly
Pathogenicity of Glycoprotein CNegative Herpes Simplex
Structure and Function of Glycoprotein D of Herpes
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Acad Sci USA activity amino acid analysis antibodies antigenic antiviral assay binding Biol BL cells Burkitt's lymphoma cell lines cell membrane cellular cloned Coen DM corneal cytomegalovirus Darai dendritic cells detected disease DNA fragment DNA polymerase DNA sequences domain EBNA2 encoded enzyme Epstein-Barr virus exonuclease factor function fusion ganglia Gen Virol gene expression genetic genome glycoprotein herpes simplex virus herpesvirus HSV Pol HSV-1 infection HSVTK human immune infected cells inhibition inoculation interaction Langerhans cells latently infected lymphoma macrophages McGeoch mice molecular mouse mRNA mutants Natl Acad Sci neomycin neurovirulence nucleotide pathogenicity peptide phenotype plasmid Proc Natl Acad promoter protein reactivation receptor recombinant region replication residues ribonucleotide reductase Roizman role simplex virus type studies subunit thymidine kinase tissues TK HSV transcription transfected tree shrews UL56 gene vaccine viral DNA viral gene virions Virology virulence viruses vitro vivo wild-type