Drug Design, Volume 8Everhardus Jacobus Ariëns |
Contents
How Should the Original Lead Be Used in the Design of Analogs? | 2 |
Which Physical Properties Should Be Related to Potency? | 16 |
Calculation Measurement and Meaning of Partition Coefficients | 28 |
Copyright | |
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acid American Chemical Society analogs analysis androgen application approach aqueous aspartame atoms binding affinity Biol biological activity calculated cation cell Chem classes of sweeteners classification clusters coding compartment complex conformation constant Copyright correlation crown ether cryptand cyclamate cyclic polyether data set derivatives descriptors determined dihydrochalcones dose drug design effects environment equation ester estradiol estrogen evaluated function glucocorticoid Hansch hormone hydrogen bond hydrophobic intensity interaction ionization J. P. Raynaud Kier ligand linear macrocyclic compounds membrane methods minipump molecular molecule OH OH organisms osmotic parameters pattern recognition Pharm physical properties pollution polyether potency predict progesterone progestin protein QSAR reaction regression relationship Reprinted with permission saccharin scopolamine selected solubility solvent specific steric Steroid structure studies substances substituent sucrose supervised learning sweet taste synthetic sweeteners Table taste receptor theophylline tion toxicity values