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13 weeks 4,4'-methylenedianiline acute animals April Arbete och Halsa benzene Bhopal Bhopal disaster bile ducts blood cancer carcinogenic cells chemical Chromosome Consensus Report Criteria Group damage days/week December 11 December 9 dermal disaster Dose-effect dose-response relationships effects of toluene Environ Health Perspect epithelium evaluation exposure levels exposure to methyl exposure to MIC exposure to toluene February 13 genotoxic guinea pigs Halsa hemoglobin hepatitis hippuric acid hours/day hyperplasia IARC increased inhalation exposure irritation of eyes isocyanic acid January 27 June liver LOAEL lung function males metabolites methyl isocyanate methylamine methylene dianiline mg/kg MIAK Montelius mutagenic Mutat Res NOAEL occupational exposure October ototoxicity ppm MIC ppm toluene rabbits rats exposed respiratory epithelium respiratory passages revised rotogravure sensory irritation September skin spontaneous abortions symptoms Teratol tests thyroid toluene exposure Toxicol Appl Pharmacol Toxicology unexposed uptake urine vitro vivo workers exposed