Microcirculatory Effects of Hemoglobin Solutions
K. Messmer, Konrad Messmer, K. E. Burhop, J. Hutter
Karger Medical and Scientific Publishers, 2004 - Medical - 106 pages
Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States. In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed. This volume summarizes the latest research on the effects of some of these new hemoglobin solutions on the microvasculature and tissue oxygenation. It is recommended reading for all those interested in finding alternatives for donor blood in transfusion medicine, including emergency specialists, anesthesiologists, surgeons, trauma surgeons and other clinicians who are frequently confronted with blood loss and the need for blood replacement.
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acute animals arterial blood pressure arteriolar arterioles base excess Baseline T0 T30 blood exchange blood flow blood substitutes blood volume Burhop capillary capillary perfusion cardiac output colloid critical hematocrit dextran 60 diaspirin cross-linked hemoglobin dorsal skinfold chamber dose Effects of Hemoglobin endothelial cells endothelium extreme hemodilution fluid Frangos functional capillary density globin hamsters Hb-Dex-BTC HBOCs heart rate hematocrit hemo hemodynamic hemoglobin DCLHb hemoglobin molecule hemoglobin solutions hemoglobin-based oxygen carrier hemorrhagic shock hypertension increase infusion Intaglietta Klinikum Grosshadern lactate lesions leukocytes Marchioninistrasse 15 mean arterial pressure Messmer microcirculation Microcirculatory Effects microcirculatory parameters microvascular perfusion myocardial nitric oxide OCPE oxygen oxygen extraction oxygen transport pancreatic patients perfusion Physiol plasma viscosity recombinant hemoglobin red blood cells red cell reduced release resuscitation rHb2.0 for injection scavenging rate shear stress side effects tion tissue oxygenation total peripheral resistance transfusion trauma Tsai vasoactive vasoconstriction venules Winslow RM
Page 94 - Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion.