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adhesion molecules angiogenesis aortic endothelial cells arteries arterioles atherosclerosis BAEC binding Biochem Biol Biology blood flow Ca2+ capillary capillary growth cardiovascular cells cultured cellular channels coronary cyclic strain cytokines decrease Droogmans dyn/cm2 dynes/cm2 E-selectin effect endothelial cells endothelial cells exposed endothelial genes endothelium etal exposure extracellular Figure fluid shear stress focal adhesion gene expression Gimbrone growth factor hemodynamic hemodynamic forces Hudlicka human endothelial cells HUVECs hydrostatic pressure hypertension induced inhibits integrin laminar shear stress Lelkes low shear M.A. Jr mechanical forces mechanotransduction membrane modulates monocyte Nerem NF-B Nilius nitric oxide PECAM-1 phosphorylation presence Prostaglandin protein kinase protein levels pulsatile receptor regulation remodeling response to shear role shear stress shear stress activation Shyy signal transduction smooth muscle cells SSRE static stimulation studies Sumpio tissue tissue factor transcription factors tyrosine phosphorylation upregulated vascular cell vascular endothelial cells vessels vitro vivo VRAC wall