Molecular Virology and Control of Flaviviruses

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Pei-Yong Shi
Horizon Scientific Press, 2012 - Science - 358 pages
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Flaviviruses are a diverse group of small RNA enveloped viruses, many of which are important human and animal pathogens. The best known include dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. These viruses are endemic in many tropical and sub-tropical regions of the world. Dengue virus alone infects over 100 million people annually. In recent years, research on flaviviruses has progressed at a remarkable rate, leading to significant advances in our understanding of virus biology. This should ultimately lead to the development of better vaccine and antiviral strategies. This up-to-date and cutting-edge anthology contains contributions from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators who have dedicated their careers to flavivirus research with those from newcomers who have recently made significant contributions to the flavivirus field. The book is divided into two sections: Molecular Virology and Virus Prevention. The first section on Molecular Virology covers: virion structure * virus replication * the NS1 glycoprotein * the NS3 protein * the NS5 protein * innate immunity and flavivirus infection * host responses to flavivirus infection * flavivirus fitness and transmission. The Virus Prevention section includes: vaccines * antibody therapy * small molecule antiviral development * flavivirus diagnostics * vector-virus interactions * vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. It is a recommended text for all virology libraries.
 

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Contents

Flavivirus Virion Structure
9
The Many Faces of the Flavivirus Nonstructural Glycoprotein NS1
51
Structure and Functions
77
Structure and Function of the Flavivirus NS5 Protein
101
Innate Immunity and Flavivirus Infection
119
Host Responses During Mild and Severe Dengue
145
Flavivirus Fitness and Transmission
163
Flavivirus Vaccines
185
Antibody Therapeutics Against Flaviviruses
231
Flavivirus Antiviral Development
257
Flavivirus Diagnostics
271
FlavivirusVector Interactions
297
Vectors of Flaviviruses and Strategies for Control
335
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