Homocysteine in Health and Disease

Ralph Carmel, Donald W. Jacobsen

Cambridge University Press, Jul 19, 2001 - Medical - 510 pages

High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have recently been identified as a very important risk factor in cardiovascular disease. Homocysteine abnormalities are also thought to contribute to birth defects and dementia. There are many common genetic disorders and problems (such as vitamin deficiency) that adversely affect the metabolism of homocysteine. In this book a team of the world's experts in the field provide a clear, current, clinical analysis of the biochemistry, genetics, and epidemiology of homocysteine disorders, providing a uniquely comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine for health and disease.

Contents

• Historical overview and recent perspectives: xvii
• Practical Chemistry of Homocysteine and Other Thiols: xxv
• Biosynthesis and reactions of homocysteine thiolactone: 3
• Unique aspects of sulfur chemistry Homocysteine and lipid oxidation: 14
• Homocysteine nitric oxide and nitrosothiols: 21
• Section Two Biochemistry and Metabolism: 29
• SAdenosylmethioninedependent Methyltransferases: 45
• SAdenosylhomocysteine hydrolase: 61
• Regulation of Homocysteine Metabolism: 76
• Folate Metabolism: 95
• Cobalamindependent remethylation: 117
• Betainedependent remethylation: 127
• The Transsulfuration Pathway: 135
• Transport and Tissue Distribution of Homocysteine and Related SAdenosyl Compounds: 145
• Homocysteine and the Kidney: 158
• Homocysteine and the Nervous System: 165
• Methodologies of Testing: 181
• Methionine Loading: 194
• Cystathionine Synthase and Its Deficiency: 205
• Inborn Errors of Folate and Cobalamin Metabolism: 226
• Polymorphisms of Folate and Cobalamin Metabolism: 241
• Folate Deficiency: 253
• Cobalamin Deficiency: 271
• Vitamin B6 Deficiency: 290
• Homocysteine in Renal Disease: 303
• Diseases and Drugs Associated with Hyperhomocysteinemia: 313
• Lifestyle Factors Associated with Hyperhomocysteinemia: 323
• Clinical Consequences in Hyperhomocysteinemia: 339
• Homocysteine and coronary artery disease: 353
• Homocysteine and cerebral vascular disease: 366
• Peripheral arterial disease: 375
• Venous disease: 383
• Homocysteine and Hemostasis: 397
• Cellular mechanisms of homocysteine pathogenesis in atherosclerosis: 407
• Homocysteine and cardiovascular physiology: 423
• Homocysteine and human reproduction TKAB Eskes: 433
• Intervention and Therapy: 449
• Design of clinical Trials to test the homocysteine hypothesis of vascular disease: 459
• What is a desirable homocysteine Level?: 467
• Index: 473

Bibliographic information

• Title: Homocysteine in Health and Disease
• Editors: Ralph Carmel, Donald W. Jacobsen
• Edition: illustrated
• Publisher: Cambridge University Press, 2001
• ISBN: 0521653193, 9780521653190
• Length: 510 pages
• Subjects: Medical / Biochemistry; Medical / Cardiology; Medical / Endocrinology & Metabolism; Medical / Hematology; Medical / Oncology / General; Medical / Pathophysiology; Medical / Psychiatry / General