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R W E WATTS Chairmans opening remarks
J S GOTS C E BENSON B JOCHIMSON and K R KODURI Microbial models
J B WYNGAARDEN and E W HOLMES JR Molecular nature of enzyme regula
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abnormalities adenosine deaminase deficiency Allison allopurinol amidophosphoribosyltransferase Biochem Biol biosynthesis de novo Burnstock cellular Chem Clin clinical coformycin concentrations of PP-ribose-P cultured cyclic AMP disease enzyme enzyme activity erythrocytes excretion fibroblasts gene genetic glutamine gout gouty growth guanine Henderson heterozygotes HGPRT activity HGPRT deficiency Hovi human hyperuricaemia hypoxanthine hypoxanthine-guanine phosphoribosyltransferase incorporation increased incubation inhibition inhibitor inosine intact cells Kelley kidney labelled Lesch-Nyhan syndrome liver lymphoblasts lymphocytes lysates McKeran mitogenic mmol/l mutant nephropathy normal novo purine synthesis nucleotides Nuki Nyhan orotic acid phosphate phosphoribosyl phosphoribosylpyrophosphate phosphorylase phytohaemagglutinin PP-ribose-P content proliferation protein purine and pyrimidine purine metabolism purine nucleotides purine overproduction purine ribonucleotides purinergic nerves pyrimidine metabolism pyrimidine nucleotides Raivio rate of purine Reem regulation regulatory renal ribose 5-phosphate Seegmiller serum small form Sperling stimulation studies substrate synthesis de novo tissue urate uric acid uridine urinary urine vitro VRIES Watts Wyngaarden