Quinolinic Acid and the Kynurenines
T. W. Stone
CRC Press, Jan 1, 1989 - Medical - 307 pages
Contributors present an up-to-date overview of existing knowledge of quinolinic acid and other kynurenines. Topics covered include: kynurenines in the CNS, kynurenine and lysosomal proteolysis, pharmacology of the kynurenine pathway, retinal actions of quinolinic and kynurenic acids, behavioral and convulsive effects, the affective disorders, skin, hepatic encephalopathy, and invertebrates. Annotation copyrighted by Book News, Inc., Portland, OR
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2,3-dioxygenase 3-hydroxyanthranilic acid 3-hydroxykynurenine 3HAO 5-hydroxykynuramine 5-hydroxytryptamine action activity agonists amino acids antagonists aspartate binding Biochem Biol Biophys block Brain Res Chem Clin compounds concentrations convulsant cortex cortical deficiency depolarization dietary doses drugs effect efflux endogenous enzyme evoked excitation excitatory amino acid glutamate hepatic hepatic encephalopathy hippocampus horizontal cells hormones increase induced inhibition inhibitory injection interaction kainate kainic acid KYNES kynuramine kynurenic acid kynureninase kynurenine kynurenine hydroxylase kynurenine pathway Lapin leucine ligands mammalian mechanisms membrane metabolism metabolites mg/kg mice Neurochem neurones Neurosci neurotoxic niacin nicotinamide nucleotides nicotinic NMDA receptors NMDLA Nutr oxidase oxidative oxygenase patients pellagra Pharmacol Pharmacology phosphoribosyltransferase picolinic plasma potential protein pyridoxal phosphate QPRT QUIN quinolinic acid quisqualate rat brain rat hippocampus rat liver release responses result Schwarcz seizures serotonin spinal cord striatal studies substrate synaptic synthesis tissue tryptophan tryptophan dioxygenase tryptophan metabolism tryptophan pyrrolase uptake urinary excretion vitamin vitro vivo xanthurenic acid