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acid-extracted lyophilized collagen alpha chains alpha-2 Aluminum Block A.B. amino acid Animals Unoperated Control antigenic apatite apatite crystals average optical densities bone formation bone grafts bony defects buffer solution C-terminal end calcification callus calvarium cell collagen fibrils Collagen Gel C.G. collagen gel implant collagen gel sites collagen molecule decalcified allogeneic bone densities of 4.00 densitometric data dentin dentin collagen Dentistry dermis diameter electron microscope evaluated Experimental fibrous Following Surgery 27 four quadrants Function of Connective gel and unimplanted granulation tissue healing hematoma holes hydroxyapatite hydroxyproline immunologic response initial lyophilized collagen implant Lyophilized Collagen L.C. lyophilized collagen sites Narang operated sites organic matrix parietal bone periosteum Piez procollagen protease protein Radiographs Rat Calvaria rate of mineralization resulted Sacrifice Interval solution Standardized Optical Density Structure and Function structure of collagen Table terworth tetracycline tropocollagen molecules Twenty-Week Animals unimplanted control sites Unimplanted Control U.I.C. unoperated control sites Unoperated Control U.0.C Weeks Following Surgery