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acid phosphatase Acta genet activity adenylate kinase adults alkaline phosphatase alleles Amer analysis antigen autosomal bands Basel BECKMAN blood groups calculated carriers cell acid phosphatase chromosome concordant consanguinity correlation dehydrogenase dermatoglyphics determined distribution Down's syndrome DZ pairs DZ twins effect electrophoretic enzyme erythrocyte estimated examined expected families females FREIRE-MAIA gene frequencies genotype Gm(a Habbanites haptoglobin HARRIS hemolysate HOPKINSON hypothesis inbreeding Indian individuals inheritance intestinal investigation isozymes linkage loci locus males marriages material mating method moderate visual defect mongolism mother normal observed parents patients patterns PGM3 PGMj phenotypes phosphoglucomutase placental alkaline phosphatase polymorphism population present probability proband protein red cell acid sample score segregation sera serum showed sibs sibships significant simian crease starch gel electrophoresis tested tongue pigmentation Total trait transferrin triplets types values variants zygosity