Erythropoietin: Molecular, Cellular, and Clinical Biology
The aim of this monograph is to provide an account of the events that led to the transformation of a concept of red cell regulation into an effective treatment of many anemias. Each chapter is authored by investigators who were involved in this transformation and who are still at work on elucidating the origin, kinetics, action, and regulation of this growth hormone. Annotation copyrighted by Book News, Inc., Portland, OR
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Recombinant Human Erythropoietin Epoetin Alfa
The Molecular Biology of Erythropoietin
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Acad Sci USA amino acid anemic antibodies baseline BFU-E binding biologic blood pressure carbohydrate cDNA cell lines CFU-E chronic renal failure clinical clones Cos cells Cotes PM dialysis dose effect end-stage renal disease epoetin alfa epoetin beta eryth erythro erythroid cells erythroleukemia erythropoi erythropoietin levels erythropoietin mRNA erythropoietin production erythropoietin receptor erythropoietin receptor protein erythropoietin-producing cells expression ferritin fetal FVA cells g/dl glycosylation GM-CSF Goldwasser growth factor hematocrit Hematol hemodialysis hemodialysis patients hemoglobin concentration hormone human erythropoietin gene hypertension hypoxia hypoxic increase interleukin intravenously iron kidney Koury liver mice molecular monkey mouse erythropoietin mRNA murine erythroleukemia cells Natl Acad Sci normal percent Pharmacokinetics placebo plasma clearance poietin Proc Natl Acad production of erythropoietin proximal tubule receptors for erythropoietin recombinant erythropoietin recombinant human erythropoietin red cell renal failure response rhuepo rhuepo therapy ropoietin serum erythropoietin subcutaneous synthesis transfusion treatment units/kg vitro vivo week