Developmental Neuropathology

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Springer Science & Business Media, Dec 6, 2012 - Medical - 577 pages
I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelino pathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the literature up to summer 1988. All refer ences were double checked for errors. My gratitude goes to Mrs. Gisela Ropte and Mrs. Cynthia Bunker for their untiring, diligent help. As a result, this second edition is an essentially rewritten text. Advance in the prevention of human suffering is based on a thorough understand ing of the nature of disease. I hope that this text will continue to be of service in this behalf. Perhaps it may also reflect and foster the intellectual curiosity which makes the "reading of brains" so interesting an occupation. Gottingen, 1989 Reinhard L.
 

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Contents

Gross and Microscopic Development of the Central Nervous System
2
Some Features of Basic Reactions Characteristic for Immature
21
Porencephaly Hydranencephaly Multicystic Encephalopathy
27
Hemorrhages in Asphyxiated Premature Infants
44
Lesions of Traumatic Birth and Other Causes of Hemorrhage
59
Perinatal Lesions of White Matter
69
Subcortical Infarcts 74 Lesions in Areas of Primary Myelination 75
75
Perinatal Lesions of Gray Matter
82
Anencephaly Rachischisis Encephaloceles and Related Lesions
277
Ventral Dysraphic and Various Sacral Lesions
291
Megalencephaly Syndromes 296 Pathology of Megalencephaly 297
297
Fetal Alcohol Syndrome 302 Syndromes with
306
Dysplasias of Cerebral Cortex
330
Dysplasias of Cerebellum
347
Dysplasias of Cerebellar Cortex
361
Dysplasias of Brain Stem and Spinal Cord
372

Postnatal Lesions of Gray Matter
98
Crossed Cerebellar Atrophy 106 Aplasia Versus Atrophy of the Cerebellar
110
Arterial Diseases in Infancy
125
Thrombosis of Intracranial Sinus and Veins
138
Cerebral Lesions in Congenital Cardiac Disease
147
Infections of the Fetus
156
Purulent Leptomeningitis in Newborns and Infants
169
Meningoencephalitic Processes in the Peri and Postnatal Periods
180
Mucor 182 Aspergillus 182 Cryptococcus 182 Coc
186
ChediakHigashi Disease 190 Familial Lymphohistiocytosis Erythro
192
Subdural Hematomas Hygromas and Effusions
198
Meningeal Cysts
209
HydrocephalusBasic Concepts and General Pathology
220
Hydrocephalus Special Pathology
231
Spina Bifida and Related Spinal Lesions
248
Forms of Hindbrain Crowding Including the ArnoldChiari Malformation
263
Dysplasias in Chromosome Anomalies
387
Dysplasias of Cerebral Vessels
395
Diseases of Carbohydrate Metabolism
406
Sphingolipidoses
425
CeroidLipofuscinosis and Miscellaneous Lipidoses
448
Metachromatic Leukodystrophy Sulfatase A Deficiency
461
Types of Arylsulfatase Deficiencies 461 Pathology of Metachromatic
467
Peroxisomal Diseases
478
Mitochondrial Diseases
490
Spongy Myelinopathies
510
Diseases of Amino Acid Metabolism
524
PelizaeusMerzbacher Disease Cockayne Syndrome
534
Patients Without Basal Ganglia Mineralization 539 Patients with
542
Axon Dystrophies
552
Subject Index
561
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