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acid activity acute adducts administration aflatoxin agents alcohol analysis animals assay assessment bioaccumulation BIOCHEM Biol blood cadmium carcinogenicity cells Cent Chem chemical chloride chromosome chronic cisplatin clinical cocaine compounds concentrations CONTAM contamination culture cytochrome cytotoxicity decreased detection dose drug En;en ENVIRON enzyme erythrocytes ethanol evaluation excretion exposed exposure ﬁsh glutathione hamster Health hepatic hepatocytes Hosp human increased induced inhibition injection inst Japan kidney levels lipid liver lung cancer male mercury metabolism metabolites metals mg/kg mice micronuclei microsomes mouse mutagenicity MUTAT Natl neurotoxicity observed occupational oxide P.O. Box patients pesticides PHARMACOL phenobarbital plasma poisoning pollution protein rats reduced renal reports respiratory risk samples selenium serum side effects signiﬁcant signiﬁcantly smoking species tion tissue toxicity TOXICOL toxin treatment tumors Univ Unlv urine vitro vivo vltro zinc