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1-Oxacephem absorption activity administration Akira animals antibacterial Antibiot antigen Asparenomycins assay Bacillus Bacillus thuringiensis behavior Benoxaprofen benzodiazepine betamethasone bile acids caerulein Carbapenem Cephalosporins Chem chemical cholecystokinin cholesterol chromatography cinoxacin compounds concentration decreased derivatives diazepam dogs dose drugs effect endocrine cells enzyme excretion fetal fetuses hepatocytes Hideo Yamada Hiroshi Hiroshi Nakai hydrolysis Ifosfamide increased induced inhibited injection insulin intravenous isolated isouron Japanese Junko Nishiitsutsuji-Uwo Kazuo Tori Kenji Kiyohisa Uchida Kobayashi lactam Latamoxef liver male Masaharu Masayuki Masuhisa Nakamura Metabolism metabolites method mg/kg mg/kg/day mice microsomes monkeys moxalactam Nagata observed octapeptide paragallinarum peptide Pharm Pharmacol pindolol plasma pretreatment protein rabbits rats reaction reactivity receptors renal results suggest serum Shinji Itoh spectra steroids strain Streptomyces structure studied substituent Synthesis Takashi Takeuchi tissues Tobramycin Tokyo toxicity uric acid urinary urine Vindesine Vindesine Sulfate vitro Yoshida Yoshihiro Yoshio Yoshio Harada Yukio