Statistical Aspects of the Design and Analysis of Clinical Trials

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Imperial College Press, 2004 - Medical - 323 pages
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Fully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer.
 

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Contents

An Introduction to Clinical Trials
1
Treatment Allocation the Size
18
Outcome
37
Basic Analyses of Clinical Trials
69
Simple Approaches to the Analysis
107
LONGITUDINAL DATA
117
Variable is Binary
132
Multivariate Normal Regression
141
Models for NonNormal Longitudinal
175
Survival Analysis
203
Bayesian Methods Longitudinal Data
250
MetaAnalysis
275
APPENDIX A Software
298
INDEX
320
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