Cancer a Comprehensive Treatise 2: Etiology: Viral CarcinogenesisThe impact of basic research on oncology has been particularly impressive in the recent search for the cause of malignancy. Equally impressive is our appreciation of the cause of tumors based on observation. Even in the earliest era of the study of infectious diseases, it was proposed that tumorous growth in animals and birds resulted from "minute" infectious particles. Experiments then supported the hypothesis, that the etiologic agent in many animal tumors was viral. The development of molecular biology, supported by technical advances and conceptual understanding of macromolecular action, led to an explosive increase in studies of animal oncogenic viruses. For a decade, new findings emerged from research laboratories revealing the enormous variety of such agents, the complex ity of their interactions with cells, and the tantalizingly possible mechanisms by which they might cause malignant transformation of the cell. Repeatedly, clues emerged which suggested the intervention of viral agents in human tumors. A breathless excitement pervaded both the scientific and public communities as highly publicized findings rapidly followed one another. The excitement was no less scientific than it was practical, for implicit in the concept of the viral oncogen is the possibility of specific virostatic or virotoxic agents or of immunization. |
Contents
The Molecular Biology of RNA | 3 |
CONTENTS | 7 |
RNADirected DNA Polymerase | 11 |
Copyright | |
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Cancer a Comprehensive Treatise 2: Etiology: Viral Carcinogenesis Frederick Becker Limited preview - 2013 |
Cancer a Comprehensive Treatise 2: Etiology: Viral Carcinogenesis Frederick Becker No preview available - 2013 |
Common terms and phrases
Aaronson Acad adenovirus antibody avian myeloblastosis virus avian RNA tumor avian sarcoma Burkitt Burkitt's lymphoma C-type Cancer Inst capsid carcinoma cats cell lines cell transformation cells infected culture cytoplasm detected DNA synthesis Duesberg embryo endogenous enzyme Epstein-Barr virus feline leukemia FeLV fibroblasts genes genetic genome hamster Hanafusa HENLE herpes simplex virus herpesviruses host cell hybridization immunological induced infected cells infectious mononucleosis isolated leukemia virus leukosis virus lymphoblastoid lymphoma mammalian type mammary tumor virus membrane mice molecular weight molecules mRNA murine leukemia mutants Natl Nature Lond Nature New Biol neoplasms nonpermissive normal oncogenic polypeptides Proc production provirus replication RNA tumor viruses RNA-directed DNA polymerase Roizman Rous sarcoma virus sequences simian virus 40 specific strains strand structural studies subgroup subunits SV40 DNA Temin THEILEN tissue TODARO transcription transformed cells type C viruses VARMUS viral DNA viral genome virions Virol Virology virus DNA virus-specific vitro Vogt