Molecular Microbiology of Heavy MetalsDietrich H. Nies, Simon Silver All forms of life depend on a variety of heavy metal ions. Nearly one-third of all gene products require a metal ion for proper folding or function. However, even metals generally regarded as non-poisonous are toxic at higher concentrations, including the essential ones. Thus, sensitive regulation of metal uptake, storage, allocation and detoxification is needed to maintain cellular homeostasis of heavy metal ions. Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements. |
Contents
| 17 | |
5 | 23 |
Part I | 75 |
Bacterial Transition Metal Homeostasis | 116 |
Biosensing of Heavy Metals | 143 |
A Glossary of Microanalytical Tools to Assess the Metallome | 159 |
Part II | 202 |
11 | 204 |
21 | 279 |
Microbial Physiology of Nickel and Cobalt | 288 |
Zinc Cadmium and Lead Resistance and Homeostasis | 321 |
According to Mechanisms | 322 |
1 | 329 |
Microbiology of the Toxic Noble Metal Silver | 343 |
Arsenic Metabolism in Prokaryotic and Eukaryotic Microbes | 371 |
3 | 392 |
14 | 213 |
New Transport Deals for Old Iron | 221 |
Uptake Biological Function and Role in Virulence | 234 |
16 | 241 |
17 | 251 |
How Bacteria Handle Copper | 259 |
Reduction and Efflux of Chromate by Bacteria | 407 |
6 | 421 |
Cervantes J ú CamposGarcía | 423 |
References | 445 |
| 452 | |