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A Quantitative Model for Relating Tumor Cell Number to Poly7
Tumor Cells Polyamines and Polyamine Derivatives
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3H-uridine Acad accumulation Acta actinomycin Ado-met decarboxylase aliquots amines amino acid amount animals assay Biochem Biol Biophys biosynthesis brain buffer cadaverine Cancer Res cations centrifugation cerebral cortex Chem chromatography Citrobacter coli Comm containing culture cyclic AMP cytolysis D. H. Russell dansyl determined dibutyryl cyclic AMP effect of spermidine enzyme activity extracts fraction GABA growth rate hepatic ODC activity hepatomas incorporation increase incubation inhibition inhibitor injection inoculation ionic strength Janne larvae lymphocytes mammalian medium method methylation Mg++ MGBG mice mouse nmoles normal nucleic acids observed ornithine decarboxylase ornithine decarboxylase activity perchloric acid phosphate Poly polyamine content polyamine levels polyamines presence Proc protein synthesis purified puromycin putrescine pyridoxal phosphate radioactivity Raina rat liver ratio RNA polymerase RNA synthesis S-adenosyl-L-methionine S-adenosylmethionine samples serum Snyder specific activity spermidine and spermine Spermidine Spermine spermidine synthase spermine stimulation studies Table tion tissue tRNA tumor cells urine virion Williams-Ashman