Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/human Herpesvirus 8
Presents the results of an expert evaluation of the carcinogenic risk to humans posed by infection with two lymphotropic herpesviruses: Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8, a new human herpesvirus detected in 1994 in Kaposi's sarcoma associated with AIDS. The viruses are evaluated in separate monographs, which consider the biology of the virus, the epidemiology of infections, related animal viruses, and mechanistic studies in addition to abundant studies of cancer in humans.
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Studies of Cancer in Experimental Animals
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acid activation antibodies antigen assays associated B-cell biopsy blood Burkitt's lymphoma c-myc Cancer carcinogenicity case—control study cellular Chinese clinical clonal controls detected domain EBER EBNA EBV DNA EBV genome EBV infection EBV-associated EBV-positive encoded Epidemiology epithelial cells epitopes Epstein Ernberg exposure factors gene expression genome glycoprotein Henle HIV-negative HIV-positive Hodgkin's disease IARC immune responses immunodeficiency in-situ hybridization incidence induced infected cells infectious mononucleosis ISBN Kaposi's sarcoma Kieff Klein KSHV KSHV/HHV8 latent membrane protein latently infected lesions lymphoblastoid lymphocytes lymphoid lymphoma cells lymphoproliferative lytic cycle monkeys monoclonal nasopharyngeal carcinoma natl Acad Niedobitek non-Hodgkin's non-Hodgkin's lymphomas nuclear antigen odds ratio Pathol patients phenotype population primary effusion lymphoma receptor recombinant region replication reported Rickinson samples sequences sera Southern blot strain T-cell lymphoma tamarins tissues titres transcription transformation transplant tumour cells vaccine viral genome Virol viruses vitro vivo