Angiogenesis and Cardiovascular Disease
J. Anthony Ware, Michael Simons
Oxford University Press, 1999 - Medical - 360 pages
Angiogenesis and Cardiovascular Disease provides a comprehensive revie w of the basic scientific and clinical advances in the field of angiog enesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of developmen t and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic card iovascular disease. Vascular development, endothelial cell biology, th e vascular matrix, and growth factors are discussed. Up to date inform ation on current clinical trials, and practical advice concerning appl ication to cardiovascular therapeutic options, are also stressed.
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Cellular Mechanisms of Angiogenesis
Heparan Sulfate Proteoglycans
Molecular Mechanisms of the Fibroblast Growth Factor
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acid activity adhesion ameroid angiogenesis angiogenic angioplasty animals atherosclerosis balloon basic fibroblast growth bFGF binding blood flow blood vessels capillary cardiac Cardiol Chem Circ circulation collateral development collateral vessels coronary artery coronary circulation coronary collateral coronary microvessels cytokines delivery domain effect embryonic endothelial cells endothelial growth factor endothelium extracellular matrix Ferrara FGF receptor fibroblast growth factor Folkman formation function gene expression gene transfer heart heparan sulfate heparin human hypertrophy hypoxia increase induced infarction inhibition injection integrin interactions ischemic isoforms left ventricular mechanism mediated mice microspheres microvascular migration mitogenic molecular molecules mRNA myocardial infarction myocardium neovascularization nitric oxide normal pathway patients PDGF perfusion phosphorylation Physiol pressure proliferation protein proteoglycans region regulation release Risau role Schaper Sellke sequence signal smooth muscle cells stimulation studies therapy tissue Tomanek tumor tyrosine kinase upregulation vasa vasorum vascular endothelial growth vasculature vasculogenesis vasodilation VEGF vitro vivo