Novel Strategies in the Design and Production of VaccinesSara Cohen, Avigdor Shafferman Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella). |
Contents
Synthetic Vaccines for Infectious and Autoimmune Diseases | 1 |
Host Ranged Restricted Non Replicating Vaccinia Virus Vectors as Vaccine Candidates | 7 |
Hybrid Hepatitis B Virus Core Antigen as a Vaccine Carrier Moiety | 15 |
Synthetic Recombinant Vaccine Induces AntiInfluenza LongTerm Immunity and CrossStrain Protection | 23 |
AlphavirusBased Expression Systems | 31 |
Alphavirus Hybrid Virion Vaccines | 41 |
DNA Vaccines for Bacteria and Viruses | 49 |
New Vaccines Against Bacterial Toxins | 55 |
HIVPeplotion Vaccine A Novel Approach to Vaccination against AIDS by Transepithelial Transport of Viral Pertides and Antigens to Langerhans Ce... | 97 |
The Role of Adjuvants and Delivery Systems in Modulation of Immune Response to Vaccines | 105 |
Unique Immunomodulating Properties of Dimethyl Dioctadecyl Ammonium Bromide DDA in Experimental Viral Vaccines | 115 |
Challenges in the Development of Combinations Vaccines | 127 |
Polysaccharide Conjugate Vaccines for the Prevention of GramPositive Bacterial Infections | 133 |
Production of Influenza Virus in Cell Cultures for Vaccine Preparation | 141 |
Analysis of Bordetella Pertussis Suspensions by Elisa and Flow Cytometry | 153 |
Clinical Trails of Shigella Vaccines in Israel | 159 |
Parameters for the Rational Design of Genetic Toxoid Vaccines | 61 |
Protective Immunity Induced by Bacillus Anthracis Toxin Mutant Strains | 69 |
Bacterial Outer Membrane Protein Vaccines | 73 |
Changing Paradigms for an HIV Vaccine | 79 |
Complexed HIV Envelop as a Target for an AIDS Vaccine | 91 |
Other editions - View all
Novel Strategies in the Design and Production of Vaccines Sara Cohen,Avigdor Shafferman Limited preview - 2013 |
Novel Strategies in the Design and Production of Vaccines Sara Cohen,Avigdor Shafferman No preview available - 2013 |
Novel Strategies in the Design and Production of Vaccines Sara Cohen,Avigdor Shafferman No preview available - 2013 |
Common terms and phrases
Acad adjuvants alphavirus antibody response antigen Arnon attenuated aureus bacterial Bordetella pertussis capsular polysaccharides cellular challenge cholera clinical Cohen coli combination vaccines conjugate vaccines cultures cytotoxic T cells diphtheria disease DNA vaccine dose efficacy elicited ELISA envelope epitopes evaluated expression gene glycoprotein Gupta HBcAg hemagglutinin hepatitis heterologous HLA class human hybrid immune response immunogenicity inactivated induced infection influenza virus inoculation Israel levels mAbs macaques MDCK mice molecules mucosal mutant Natl neutralizing antibodies Novel Strategies oral pathogen peptides pertussis toxin plasmid polysaccharides present Proc Production of Vaccines protective immunity proteosomes recombinant replication replicons Salmonella Schödel sequence serum antibodies serum IgG Shafferman Shigella shigellosis Siber specific strains Strategies in Design structure studies subunit synthetic peptides T-cell tetanus tetanus toxoid titers titres typhimurium vaccine development Vaccines Edited vaccinia virus vector Vero cells viral Virol virus production viruses vitro
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