Focal Infection: The Lane Medical Lectures

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D. Appleton, 1916 - Pathology - 166 pages
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Page 40 - Nine strains of streptococcal organism from epidemic parotitis produced lesions in one or both parotid glands in 73 per cent, of the nineteen animals injected intravenously, in contrast to no instance of lesions here with the other strains. Three strains from cases of true myositis produced myositis in 75 per cent, and myocarditis (chiefly of the right ventricle) in 35 per cent, of the forty animals injected, in contrast to an average of myositis of 12 per cent, and myocarditis of 10 per cent, following...
Page 44 - A careful study of smears of the suspensions injected in these experiments revealed no constant relation between localization and clumping or size of the bacteria. Individual variations in resistance to infection were found in the injected animals. The effects of these conditions in the host as determining factors in localization are important ; they are probably expressions of differences in metabolism, oxidation rates, etc., which influence the soil for bacteria.
Page 44 - it appears that the cells of the tissue for which a given strain shows elective affinity, take the bacteria out of the circulation as if by a magnet—absorption.
Page 131 - Deplorable as the loss of teeth may be, that misfortune is justified if it is necessary to obliterate the infectious focus which is a continued menace to the general health.
Page 37 - C. in tall columns of ascites-dextrose broth (affording a gradient of oxygen pressure), for from eighteen to twenty-four hours, centrifugalized in the containers in which they were grown, the supernatant broth saved for filtration and for injection of animals, and the sediment suspended in sodium chlorid solution, so that 1 cc represented the growth from 15 cc of the broth culture. Animals of different species were injected, often in series, with doses ranging generally from 1 to 3 cc of the suspension...
Page 94 - That herpes zoster may be the result of specific infection of the ganglia of the posterior roots of the spinal nerves and the...
Page 3 - A focus of infection is defined as a "circumscribed area of tissue infected with pathogenic micro-organisms," which may be primary or secondary, and the author states that " infection of the teeth and jaws, with the especial development of pyorrhea dentalis and alveolar abscess, infection of the faucial and naso-pharyngcal tonsils and of the mastoid, the maxillary and other accessory sinuses, are the most common forms of focal infection.
Page 161 - A further contribution to the study of rheumatism; the experimental production of appendicitis by the intravenous inoculation of the diplococcus.
Page 41 - ... no other focal lesions could be found except those in the organ in question ; and when the animal died early, these lesions were the marked feature and the associated ones were relatively insignificant. Frequently the injection of a very small dose was sufficient to prove the elective localization. In many cases of both acute and chronic diseases the apparent atrium of infection was found to harbor streptococci having elective affinity; in the former usually only at the time of the attack, in...
Page 40 - Six strains from erythema nodosum produced lesions of the skin in 90 per cent, of twenty animals injected, in contrast to an average of 2 per cent, in the animals injected with the strains from sources other than erythema nodosum and herpes zoster. Eleven strains from herpes zoster produced herpetiform lesions of the skin, lips, tongue or conjunctivae in 77 per cent, of the sixty-one animals injected, in contrast to the average of only 1 per cent, of what seemed to be herpes of the skin with the...

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