The Regulatory Genome: Gene Regulatory Networks In Development And Evolution

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Elsevier, Jul 19, 2010 - Science - 304 pages
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Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology.

The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market.

  • The only book in the market that is solely devoted to the genomic regulatory code for animal development
  • Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding
  • Presents a comprehensive treatment of molecular control elements that determine the function of genes
  • Provides a comparative treatment of development, based on principles rather than description of developmental processes
  • Considers the evolutionary processes in terms of the structural properties of gene regulatory networks
  • Includes 42 full-color descriptive figures and diagrams

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1 The Regulatory Genome for Animal Development
2 cisRegulatory Modules and the StructureFunction Basis of Regulatory Logic
3 Development as a Process of Regulatory State Specification
What They Are How They Work and What They Mean
The Roots of Causality and Diversity in Animal Evolution
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Page 264 - R. (1996). A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila. Development 122, 402.3-4031.
Page 261 - C. (1996) Analysis of Hox gene expression in the chick limb bud. Development 122, 1449-1466.
Page 261 - RA (2004). Control of pancreas and liver gene expression by HNF transcription factors. Science 303, 1378-1381.
Page 261 - Nasevicius, A. and Ekker, SC (2000) Effective targeted gene 'knockdown

About the author (2010)

Isabelle S. Peter is Assistant Research Professor and Eric H. Davidson is Norman Chandler Professor of Cell Biology in the Division of Biology and Biological Engineering at the California Institute of Technology, Pasadena, California. Over the last seven years they have co-authored a series of works on experimental, conceptual and computational analyses of developmental gene regulatory networks, including their evolutionary significance. The discussions and conceptual explorations occasioned by this collaboration produced the new synthetic views encompassed in this book, building on decades of earlier work summarized in the 2001 and 2006 Academic Press books by Eric H. Davidson.

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