Oxygen Radicals in the Pathophysiology of Heart Disease

Front Cover
Pawan K. Singal
Springer Science & Business Media, Dec 6, 2012 - Medical - 348 pages
Over two centuries ago, oxygen was discovered as "air vital": the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research.
 

Contents

BIOLOGICAL SYSTEMS WHICH SUPPRESS LIPID PEROXIDATION 13
12
CONTRASTING FEATURES OF PEROXIDE METABOLISM IN HEART
25
FREE RADICAL AND IRONMEDIATED INJURY IN LYSOSOMES
41
MYOCARDIAL EFFECTS OF PARTIALLY REDUCED FORMS
55
OXYGEN RADICAL MEDIATED PROTEIN OXIDATION IN HEART
71
THE ROLE OF OXYGEN FREE RADICALS DURING THE COURSE
110
THE ROLE OF THE POLYMORPHONUCLEAR LEUKOCYTE
123
ALTERATIONS OF GLUTATHIONE STATUS DURING MYOCARDIAL
145
ROLE OF OXYRADICALS IN POSTISCHEMIC MYOCARDIAL
203
ACUTE EFFECTS OF ANTIOXIDANTS ON IN VIVO MODELS
227
DO FREE RADICALS CONTRIBUTE TO THE GENESIS
238
IMPORTANCE OF ELECTRON TRANSFER THROUGH
261
ROLE OF ANTIOXIDANTS IN HYPOXIAREOXYGENATION INJURY
270
THE ROLE OF LIPID PEROXIDATION IN THE MYOCARDIUM
285
REACTIVE OXYGEN RADICAL PROCESSES IN DIABETES 303
302
ANTHRACYCLINEENHANCED CARDIAC OXYGEN RADICAL
323

ALTERATIONS IN MEMBRANE PHOSPHOLIPIDS MECHANISMS
161
THE MEASUREMENT OF CONJUGATED DIENES IN ISCHEMIC
177
XANTHINE OXIDASE IS NOT LIKELY TO BE A SOURCE
189
CONTRIBUTIONS OF LEUKOCYTES TO VASCULAR INJURY
333
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