Stem Cells and Cell Signalling in Skeletal MyogenesisD.A. Sassoon Skeletal muscle development is perhaps one of the best understood processes at the molecular, cellular and organismal level due in large part to the fact that primary myogenic cells (myoblasts) will grow and subsequently differentiate into myotubes in culture. With the advent of reverse mouse genetics, many of the observations gained through the study of myogenic cells in vitro have been directly tested in vivo. What has emerged is a complex but cohesive story of how myogenic cells are initially specified in the vertebrate embryo and how muscle fibers ultimately achieve their respective identities (i.e. fast versus slow) to perform their function. This collection of chapters is focused on these developments. The book discusses old and new directions for the skeletal muscle field and points out directions where the field may eventually progress. |
Contents
Chapter 2 Myofiber Specification and Survival | 33 |
Chapter 3 Interactions Between The Cell Cycle and The Myogenic Program | 53 |
Chapter 4 Fiber Type Specification in Vertebrate Skeletal Muscle | 75 |
Chapter 5 Role of Cytokines in Skeletal Muscle Growth and Differentiation | 97 |
Chapter 6 Somitic and Non Somitic Progenitors of Skeletal Muscle | 127 |
Contributor Addresses | 143 |
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Common terms and phrases
Acad Sci USA adult bHLH Biol Chem Borycki Braun calcineurin calpain cell lines Cossu culture cyclin Dev Biol domain embryos epaxial fast fetal Florini function gene expression Genes Dev Hauschka helix-loop-helix hypaxial hypertrophy induce inhibitor inhibits insulin-like growth factor interaction isoforms Lassar limb bud lineage MAPK MDM2 mediated MEF2 mesoderm Mol Cell Biol mouse MRF4 MRFs muscle development muscle differentiation muscle gene muscle specific gene muscle-specific mutant mice Myf5 Myf5 expression MyHC myoblast differentiation myoblast proliferation myoblasts myocyte MyoD MyoD activity myofibers myogenesis myogenic cells myogenic differentiation myogenin myosin myotome myotubes Natl Acad Sci Olson Pax3 Pax7 phenotype phosphorylation Physiol primary Proc Natl Acad progenitors promote protein kinase receptor regulation regulatory retinoblastoma rhabdomyosarcoma role Rudnicki satellite cells signaling pathways skeletal muscle skeletal muscle cells slow muscle somite Sonic hedgehog stem cells stimulation Tajbakhsh terminal differentiation tissue transcription factors transcriptional activity vitro vivo Weintraub
Popular passages
Page 140 - Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, IL, and Grompe, M. (2000). Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.
Page 140 - T. (1994). Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol.