Clostridium difficile, Volume 250
K. Aktories, T.D. Wilkins, T. C. Wilkins
Springer Science & Business Media, Jul 6, 2000 - Medical - 143 pages
Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.
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Microbiology Epidemiology and Diagnosis of Clostridium difficile Infection
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actin actin cytoskeleton Aktories amino acids antibiotic-associated antibiotics antibody assay bacterial binding Biol Chem Borriello Brazier Castagliuolo cell lines cellular Chaves-Olarte Clin Invest Clin Microbiol clinical cloning Clostridium difficile toxin Clostridium difficile-associated Clostridium novyi Clostridium sordellii Clostridium sordellii lethal cytoskeleton cytotoxic cytotoxin detection diagnosis difficile colitis difficile diarrhea difficile-associated diarrhea domain effector Eichel-Streiber CV enterotoxin enzymatic enzyme epithelial factors faecal Fiorentini function fusidic acid glucosylation glucosyltransferase GTP-binding proteins Hofmann F hospital Infect Immun intestinal ISBN isolates Kelly CP kinase laboratory LaMont JT large clostridial cytotoxins LT Toxin.A ALPHA Lyerly DM membrane method metronidazole molecular monoglucosylated N-terminal nucleotide outbreak pathogenicity patients PCR ribotyping Popoff Pothoulakis protein substrate pseudomembranous colitis receptor repeating units Rho proteins ribotyping Selzer sequence serogroup signalling sordellii lethal toxin stool teicoplanin Thelestam toxigenic toxin A gene Toxin.A ALPHA Toxin ToxinB LT Toxin.A treatment txeR typing UDP-glucose vancomycin vitro Wilkins TD