Ancestral Sequence Reconstruction
David A Liberles
OUP Oxford, May 31, 2007 - Science - 252 pages
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including wholeproteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized toprovide insights and inform future research.This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
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aldosterone algorithm amino acid amino acid sequences analysis AncCR ancestral gene ancestral proteins ancestral reconstruction ancestral sequence reconstruction ancient approach archosaur assay bacterial Bayesian behavior Beintema Benner Bioinformatics Biol biology branch lengths changes Chapter clusters codon computed conserved covarion Danchin data-set database dehydrogenase Ecdysozoa enzymes estimate eukaryotic Evol evolutionary experimental extant Figure functional divergence Gaucher gene duplication Genet genome homologous hormone hypothesis inferred last common ancestor likelihood lineages matrices maximum-likelihood mesophilic methods molecular multiple sequence alignment mutational Natl neighbor-joining nucleotide oligonucleotides orthologous paleogenetics paralogs parsimony phylogenetic tree phylogeny position posterior probability prediction probabilistic sequence protein families protein sequences proteome Pupko rare variants receptor reconstructed ancestral reconstruction of ancestral regions residues resurrected rhodopsin ribonuclease RNase sampling selection seminal RNase sequence alignment species statistical steroid structure subfamilies substitution synthesis synthetic biology taxa thermophilic Thornton tion topology vertebrates yeast Zhang