Bioprocess Engineering Principles
The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.
This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems.
* First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists
* Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems
* Comprehensive, single-authored
* 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems
* 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors
* Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading
* Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used
* Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.
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acid adsorbate adsorption analysis applied batch culture Bioeng biomass bioprocessing bioreactors Biotechnol boundary layer bubbles calculated catalyst cell concentration centrifuge Chapter Chemical chemostat chromatography column component constant cooling density depends diameter diffusion energy energy-balance engineering enthalpy enzyme equation equilibrium ethanol example fed-batch fermentation filter filtration first-order fluid function gluconic acid glucose gmol heat of combustion heat transfer heat-transfer coefficient immobilised impeller increases kinetics liquid mass balance mass flow rate mass transfer mass-balance mass-transfer coefficient measured medium metabolism mixing molecular moles operation oxygen parameters particle phase plasmid plot pressure protein pseudoplastic rate of reaction reactant reaction rate reactor Section shear shown in Figure solid solution specific growth rate sterilisation stirred stirrer speed stream substrate substrate concentration sucrose surface Table tank temperature tion total mass units variables velocity vessel viscosity volume volumetric rate zero-order