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Volume of Distribution
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Abscissa absorption occurs amount of substance analogue computer ascorbic acid Bateman function bilirubin blood concentration blood concentration-time curve body bromsulphalein calculated chloramphenicol chyme coefficient of distribution compartment concentration curve concentration y0 constant of elimination continuous infusion depot determined differential equations distribution space dosage dose-interval Dost drug effect elimination constant endogenous enzyme enzyme induction enzyme kinetics equilibrium example excretion experimental exponential function extracellular fluid fraction gastrointestinal absorption given gives graph half-time of elimination increase indocyanine green intestinal intramuscular intravenous administration intravenous injection invasion and elimination invasion constant invasion curve kinetics linear liver logarithmic mathematical measured mg/kg mg/litre neonate obtained ordinate pharmacokinetic pharmacokinetic model phase phenobarbitone phenylbutazone plasma potentiometer procedure processes proportional protein quantity of substance rate constant rate of elimination ratio renal serum shows steady straight line substance absorbed sulphonamides Table test substance theoretical initial concentration total clearance urine volume of distribution