Molecular Pathogenesis of Gastrointestinal InfectionsT. Wadström, P. Helena Mäkelä, A.M. Svennerholm, H. Wolf-Watz The meeting that provided the material for this book was the 58th Symposium of the Federation of European Microbiological Societies (FEMS) entitled MOLECULAR PATHOGENESIS OF GASTROINTESTINAL INFECTIONS which was held in Helsingor, Denmark from 2nd to 4th September, 1990. The aim of this meeting was to bring together scientists from a range of discipline- microbiology, cell biology, molecular biology and immunology - to consider how microbes, including parasites, colonize and infect the gastrointestinal tract. The programme was designed to focus particular attention on the range of strategies whereby enterovirulent bacteria and parasites colonize the gastrointestinal mucin layer, how they adhere to and penetrate the epithelial layer by entering the cells or passing between them, and how various protein toxins may facilitate these processes. Speakers were especially encouraged to highlight the recent expansion in our knowledge of the molecular mechanisms by which enterotoxigenic and enteropathogenic Escherichia coli, shigellae, salmonellae and Yersinia enterocolitica cause intestinal disease. There were also discussions of recently-discovered gastrointestinal pathogens such as Clostridium difficile and Helicobacter pylori as well as accounts of how virulent determinants can be used to develop new diagnostic methods based on DNA gene probes and the polymerase chain reaction (PCR). These presentations provided the basis for the chapters in this book. |
Contents
| 1 | |
Structure and Properties of Rat Gastrointestinal Mucins | 23 |
The Role of Large Intestine Mucus in Colonization of | 29 |
Bacterial Glycosidases and Degradation of Glycoconjugates | 37 |
The Clone Concept and Enteropathogenic Escherichia coli EPEC | 49 |
Newly Characterized Putative Colonization Factors | 79 |
Molecular Biology of Escherichia coli Type 1 Fimbriae | 87 |
Intestinal Colonization by Enteropathogenic Escherichia coli | 93 |
Vero Cytotoxins ShigaLike Toxins of Escherichia coli | 155 |
Structure and Function of Clostridium difficile Toxins | 161 |
On the Cytotoxic Modes of Action of Clostridium difficile Toxins | 169 |
1990 | 185 |
Colonization of the Murine Gastrointestinal Tract | 197 |
Plasmid Encoded Virulence of Yersinia | 207 |
DNA Probes and PCR Analysis in the Detection of Clostridium | 273 |
The Development of Genetically Defined Live Bacterial Vaccines | 279 |
Diffuse Adherence of Enteropathogenic Escherichia coli Strains | 103 |
Cholera | 111 |
HeatStable Enterotoxins Produced by Enteric Bacteria | 125 |
Molecular Analysis of Potential Adhesions of Vibrio cholerae 01 | 139 |
Shigella Toxin and Related Proteins | 147 |
207 | 284 |
Comparison of Virulence Factors in Different Freshly Isolated | 295 |
G Jonson A M Svennerholm and J Holmgren | 315 |
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Molecular Pathogenesis of Gastrointestinal Infections T. Wadström,P. Helena Mäkelä,A.M. Svennerholm,H. Wolf-Watz No preview available - 2013 |
Common terms and phrases
activity adherence adhesins adhesion amino acid antibodies antigens assay attenuated bacteria binding blood group brush border CFA/I cfaD cloned Clostridium difficile coli F18 coli strains colonization factor antigens components culture cytotoxic detected diarrhoea disease E.coli encoding enterocytes enteropathogenic enterotoxigenic Escherichia coli enterotoxin enzyme EPEC epithelial cells Escherichia coli ETEC expression fecal fimbriae fragment gastric Gastrointestinal Infections gene genetic glycolipids glycoproteins glycosidases haemagglutination Helicobacter pylori HEp-2 cells human hybridisation identified Immun incubation inhibition interaction intracellular invasion isolated mediated mice microbial Microbiol Molecular Pathogenesis mouse mucin mucosal mucus mutants Nucleotide sequence oligosaccharide operon outer membrane Pathogenesis of Gastrointestinal pathogenic peptides phenotype plasmid probe produced purified rabbit receptor regulation regulatory role Salmonella typhimurium serotype Shiga toxin Shiga-like toxin Shigella dysenteriae Shigella flexneri shown specific STII structure studies subunit Svennerholm tissue TnphoA transcription type 1 fimbriae urease Vibrio cholerae virulence vitro vivo Yersinia