Listeria monocytogenes: Pathogenesis and Host Response
Howard Goldfine, Hao Shen
Springer Science & Business Media, Jun 24, 2007 - Science - 287 pages
We are at the beginning of the third decade of studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections. It is a good time to survey the wealth of information that these studies have revealed and to think about perspectives for a more complete understanding of this important pathogen. During the past 20 years, L. mono- togenes has emerged from relative obscurity to being one of the most intensely studied bacterial pathogens. In the opening chapter, Daniel A. Portnoy provides a personal and historical account of the development of our understanding at the molecular level of invasion of the host cell, growth in the cytosol, and ce- to-cell spread by means of actin polymerization-powered motility. We are also fortunate to have contributions from Pascale Cossart and Werner Goebel and their colleagues. These pioneering investigators continue to make major cont- butions to the molecular description of almost every aspect of L. monocytogenes pathogenesis. All chapters in this book have been written by experts who have contributed widely to this field. We are extremely grateful for the efforts of all contributors who have provided contemporary accounts of the status of various aspects of L. monocytogenes pathogenesis and the host response. Their positive responses to this effort are deeply appreciated. Any specialist volume in the biological sciences can only provide a snapshot of the field at the time of its publication.
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ActA actin actin filaments actin polymerization actin-based motility activity antigen Arp2/3 complex autolysins Bacteriol bacterium CD8+ T cells Cell Biol cell wall cell-to-cell spread cellular Chakraborty Clin comet tails Cossart cytoskeleton cytosol domain E-cadherin Ena/VASP encoding enzymes function gene expression gene products genome sequence Goebel Goldfine gram-positive growth Harty host cell human listeriosis identified immune response Immunol Infect Immun InlA InlB innocua interaction internalin intracellular invasion Lecuit lineage lineage II Listeria monocytogenes Listeria monocytogenes infection listeriolysin listeriosis LPXTG proteins macrophages mammalian mediated membrane metabolism MHC Class mice modules Mol Microbiol molecular molecules monocy monocytogenes EGDe monocytogenes strains monocytogenes virulence mutant Natl Acad Sci operon pathogen pathogenesis pathways PC-PLC peptidoglycan phage phagosome phospholipase Portnoy PrfA Proc Natl Acad proteins proteome receptor regulation ribotyping role serotype serovar sortase specific studies subtilis subtyping surface proteins T-cell Theriot togenes transcription vacuole Vazquez-Boland virulence factors virulence gene Wehland Wiedmann