Free Radicals in Biology and Medicine
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
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8OHdG 8OHG acid activity agents aldehydes animals antioxidant antioxidant defences apoptosis ascorbate assay atherosclerosis bacteria bind biomarkers blood brain Ca2+ cancer carbonyls carotenoids catalase cause cells chelates compounds contain copper CuZnSOD cytochrome cytokines decreased detected diabetes disease DNA damage effects electron elevated endothelial enzymes erythrocytes example F2IsoPs factor Fe2+ ferritin fluids formation free radicals genes encoding glutathione haem HOCl human inactivation increased inflammation inhibit inhibitors injury intracellular involved kinase levels lipid peroxidation liver lung macrophages mechanisms membrane metabolism metal ions mice lacking mitochondrial MnSOD molecules mutations NADPH oxidase neurons neutrophils nitration normal ONOO oxidative damage oxidative stress patients peroxidase peroxiredoxins phagocytes plants plasma promote prooxidant proteasome protect proteins rats react reaction reactive receptors redox reduced reductase release residues role scavenge Section singlet O2 species studies substrate superoxide synthesis Table thiols thioredoxin tissues tocopherol toxicity tumour tyrosine vitamin vitamin E vitro vivo