LC-MS in Drug Bioanalysis

Front Cover
Q. Alan Xu, Timothy L. Madden
Springer Science & Business Media, Jul 15, 2012 - Science - 472 pages
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Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
 

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Contents

Internal Standards for Quantitative LCMS Bioanalysis
1
Method Development Validation and Sample Analysis for Regulated Quantitative Bioanalysis Using LCMSMS
33
Impact of Sampling PaperCards on Bioanalytical Quantitation via Dried Blood Spots by Liquid ChromatographyMass Spectrometry
67
Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective SolidPhase Extraction Coupled to Microflow Liquid Chromatography and Isot...
81
Pitfalls of LCMSMS in the Clinical Laboratory
109
Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics
127
Liquid ChromatographyMass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matr...
143
The Analysis of Antipsychotic Drugs in Human Biosamples by LCMS
177
Therapeutic Drug Monitoring of Targeted Anticancer Therapy Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators A Clinical Ph...
197
Applications of Mass Spectrometry in Analyses of Steroid Hormones
251
Liquid ChromatographyMass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples Techniques and Applications
287
Analysis of Illicit Drugs in Human Biological Samples by LCMS n
349
Use of Matrix Assisted Laser DesorptionIonization Imaging Mass Spectrometry MALDIIMS in the Development of Novel Small Molecule Drugs
399
A Planar Integrated Micromass Spectrometer
423
Index
466
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