Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction

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Amitava Dasgupta, Jorge L. Sepulveda
Newnes, Jan 22, 2013 - Science - 382 pages
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This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.

  • Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises
  • Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference
  • Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks
  • Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
 

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Contents

1 Variation Errors and Quality in the Clinical Laboratory
1
2 Effect of Age Gender Diet Exercise and Ethnicity on Laboratory Test Results
9
3 Effect of Patient Preparation Specimen Collection Anticoagulants and Preservatives on Laboratory Test Results
19
4 Sample Processing and Specimen Misidentification Issues
35
5 Hemolysis Lipemia and High Bilirubin
53
6 Immunoassay Design and Mechanisms of Interferences
63
7 Effect of Herbal Remedies on Clinical Laboratory Tests
75
8 Challenges in Routine Clinical Chemistry Testing
93
13 Issues of Interferences in Therapeutic Drug Monitoring
195
14 Limitations of Drugs of Abuse Testing
213
15 Challenges in Confirmation Testing for Drugs of Abuse
233
16 Alcohol Determination Using Automated Analyzers
247
17 PreAnalytical Issues and Interferences in Transfusion Medicine Tests
273
18 Issues with Immunology and Serology Testing
295
19 Sources of Errors in Hematology and Coagulation Testing
305
20 Challenges in Clinical Microbiology Testing
315

9 Challenges in Routine Clinical Chemistry Analysis
131
10 Sources of Inaccuracy in Biochemical Genetics Testing
149
11 Challenges in Endocrinology Testing
155
12 Pitfalls in Tumor Markers Testing
177
21 Sources of Errors in Molecular Testing
327
22 Problems in Pharmacogenomics Testing
343
Index
357
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About the author (2013)

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

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