Elsevier, Oct 9, 1996 - Science - 474 pages
Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists.
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Chapter 3 The stem cell concept applied to shoot meristems of higher plants
function and potential role in therapy
Chapter 5 Cell progenitors in the neural crest
Chapter 6 Phenotypic diversity and lineage relationships in vascular endothelial cells
Chapter 7 Mammary stem cells in normal development and cancer
Chapter 8 Liver stem cells
Chapter 10 Stem cell repertoire in the intestine
Chapter 11 Keratinocyte stem cells of cornea skin and hair follicles
Chapter 12 Tumour stem cells
Chapter 13 Biology of the haemopoietic stem cell
Chapter 14 Growth factors and the regulation of haemopoietic stem cells
Chapter 15 Haemopoietic stem cells for gene therapy
Color Plates Section
Chapter 9 Regulation of proliferation and differentiation of stem cells in the male germ line
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apical assay Barraclough basal benign bFGF blood bone marrow breast Cancer Res carcinomas cell cycle cell division cell lineages cell numbers cell proliferation cell types cellular CFU-S clonal clones clonogenic colonies compartment corneal crest cells crypt culture cytokines differentiation ductal ducts endothelial cells epidermal epithelial cells epithelium expression fibroblasts Figure functional gene glial gonocytes Grisham growth factors haematopoietic stem cells haemopoietic hepatic hepatocytes human keratinocytes liver epithelial cells Loeffler malignant mammary gland markers mature meristem mice migration molecular mouse mRNA muscle fibres mutation myoblasts myoepithelial cells myoepithelial-like cells Natl Acad neural crest normal oval cells p9Ka Pathol pericytes peripheral PGCs phenotype Physiol pluripotent potential Potten precursor Proc produced progenitor cells proliferative protein Rama receptors regeneration root Rudland satellite cells Schor self-maintenance Sertoli cells spermatogonia staining stimulate stromal structures studies suggest TEBs tissue transit cells transplantation tumour undifferentiated spermatogonia vitro vivo
Page ix - Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 ONN.
Page viii - Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.