Imaging Drug Action in the Brain

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CRC Press, Dec 21, 1992 - Medical - 432 pages
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Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail.

Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
 

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Contents

Preface V
5
Receptor Autoradiography as an Aid
49
Studies of Benzodiazepine Receptors Using
81
CNS Receptors for Opioids
119
Imaging Neuroreceptors to Study Drug Action
177
Metabolic Mapping with Deoxyglucose
207
Metabolic Mapping of the Effects
247
Positron Emission Tomographic Studies on
266
Use of PET to Study Addiction in Humans
281
InterRater Reliability in Positron Emission
297
Immunohistochemistry as a Strategy
324
In Situ Hybridization Histochemistry
337
Identifying and Localizing Gene Expression
379
Advanced Electrophysiological Imaging
389
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