Experimental Pharmacogenetics: Physiopathology of Heredity and Pharmacologic Responses |
Contents
INTRODUCTION | 1 |
FACTORS INFLUENCING DRUG METABOLISM | 5 |
Influence of Age and Sex | 6 |
Copyright | |
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abnormal acid action activity addition adrenal alterations amount anemia animals appeared assays biochemical blood brain breeding caused cells changes characteristics cholesterol cholinesterase clotting compared compounds condition decrease defect deficiency determined diabetes diet differences dilute disease dogs doses drug dystrophic effects enzyme et al evidence excretion experiments fact factor females findings formation gene genetic gland glucose greater growth guinea pigs hamster hereditary hormone human inbred strains incidence increased indicate induced influence inherited inhibition insulin interest involved known laboratory lesions less levels litters liver males measured mechanism Meier metabolism mice mouse mutant Nature normal obese observed obtained occur pharmacologic pituitary plasma possible present produced protein prothrombin rabbit rats reactions recently reduced relative reported response serum showed significant similar species spontaneous stocks studies suggested synthesis tion tissue tumors values various vitro weeks weight
