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Sickle Cell Disease in Children
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abdominal acute adult Africa Amer amino acid appeared areas arterial aseptic necrosis associated with sickle autopsy beta chain bone capillaries cardiac caused cerebral changes children with sickle chronic Clin clinical complications concentration demonstrated described diagnosis dilatation electrophoresis erythrocytes factor fever fibrosis frequently genetic globin hematuria hemo hemoglobin C disease hemorrhage hepatic homozygous homozygous sickle cell incidence increased infection kidney lesions liver malaria marrow molecule mutation necrosis normal observed occlusion occur osteomyelitis oxygen tension pain patients with sickle percent plasma pregnancy present priapism protein pseudoxanthoma elasticum pulmonary red blood cells red cells renal reported result retinal revealed rheumatic Salmonella serum showed sickle cell anemia sickle cell crisis sickle cell disease sickle cell gene sickle cell hemoglobin sickle cell trait Sickle-Cell Anemia sickled erythrocytes sicklemia sickling phenomenon spleen splenectomy splenic infarction stasis suggested symptoms syndrome thalassemia therapy thrombi thrombosis tion tissue transfusions ulcers urine vascular venous vessels