The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence

Front Cover
Daniel Steinberg
Elsevier, Apr 28, 2011 - Science - 248 pages
Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.
  • Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community
  • Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
  • Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis
 

Contents

Chapter 1 Overview
1
Chapter 2 Animal Models of Atherosclerosis
15
Causally Related?
27
Chapter 4 Building the Basic Science Foundation
63
Chapter 5 In Search of a Pathogenesis
89
Chapter 6 The Search for Cholesterollowering Drugs
125
Chapter 7 The 1984 Coronary Primary Prevention Trial
143
Chapter 8 Inhibition of Cholesterol Biosynthesis the Discovery of the Statins and a Revolution in Preventive Cardiology
171
Chapter 9 Summing up
195
Appendix Frequently cited criticisms
205
Glossary
215
Index
221
Color Plate Section
229
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