The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence
Elsevier, Apr 28, 2011 - Science - 248 pages
Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.
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Acad Sci U.S.A. all-cause mortality animal Anitschkow atherogenesis atherogenic atherosclerosis Biol Chem blood cholesterol levels Brown choles cholesterol biosynthesis cholesterol lowering Cholesterol Wars cholesterol-fed rabbits cholesterol-lowering cholestyramine clinical trial clofibrate compactin coronary artery coronary heart disease Coronary Primary Prevention CPPT decrease diet drug effect Endo endothelial Engl evidence experimental factors familial hypercholesterolemia fatty streak Figure foam cells Fredrickson genetic Gofman Goldstein heart attack heart disease risk incidence of coronary increase inhibition inhibitor JAMA laboratory Lancet LDL cholesterol LDL levels LDL receptor lesions lesterol lipid hypothesis Lipid Research Clinics lovastatin low density lipoprotein lowering blood cholesterol lowering cholesterol levels macrophages Medical Merck metabolism mg/dl monocytes myocardial infarction nicotinic acid normal oxidized Panel patients percent plasma cholesterol Primary Prevention Trial probucol protein reduce reductase saturated fat serum cholesterol showed smooth muscle cells statin statistically significant Steinberg studies terol total cholesterol toxic treatment xanthomas