The Cholesterol Wars: The Skeptics vs the Preponderance of EvidenceDaniel Steinberg Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future. - Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community - Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs - Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis |
Contents
| 1 | |
| 15 | |
Causally Related? | 27 |
Chapter 4 Building the Basic Science Foundation | 63 |
Chapter 5 In Search of a Pathogenesis | 89 |
Chapter 6 The Search for Cholesterollowering Drugs | 125 |
Chapter 7 The 1984 Coronary Primary Prevention Trial | 143 |
Other editions - View all
The Cholesterol Wars: The Skeptics Vs. the Preponderance of Evidence Daniel Steinberg No preview available - 2007 |
Common terms and phrases
Acad Sci U.S.A. animal Anitschkow atherogenesis atherogenic atherosclerosis Biol Chem blood cholesterol levels Brown choles cholesterol biosynthesis cholesterol lowering Cholesterol Wars cholesterol-fed rabbits cholesterol-lowering cholestyramine Clin clinical trial clofibrate compactin coronary artery coronary heart disease Coronary Primary Prevention CPPT decrease diet Diet-Heart drug effect Endo endothelial Engl evidence experimental factors familial hypercholesterolemia fatty streak Figure foam cells Fredrickson genetic Gofman Goldstein heart attack heart disease risk increase inhibition inhibitor JAMA laboratory Lancet LDL cholesterol LDL levels LDL receptor lesterol lipid hypothesis Lipid Research Clinics lovastatin low density lipoprotein lowering blood cholesterol lowering cholesterol levels macrophages Medical Merck metabolism mg/dl monocytes myocardial infarction Natl Acad Sci nicotinic acid normal oxidized Panel patients percent plasma cholesterol Primary Prevention Trial probucol Proc Natl Acad protein reduce reductase saturated fat serum cholesterol showed smooth muscle cells statin statistically significant Steinberg studies terol toxic treatment xanthomas