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Identification of Peptides for Immunotherapy of Cancer It Is Still Worth the Effort
P53based Immunotherapy of Cancer
Issues in Vaccine Development
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ability Acad activation addition adhesion analysis antibodies antigen apoptosis appears associated binding Biol blood Ca2+ cancer caspase CD4+ CD8+ cell lines clones complex culture cytokine cytoplasmic cytotoxic demonstrated dendritic detected determined differentiation disease domain early effect epitopes expression factor Figure function gene growth human identified immune response Immunol Immunology important increased indicate induced infection inhibition initial interaction involved kinase levels ligand lymphocytes major mechanisms mediated melanoma mice molecules mouse murine mutations Nature normal observed occur pathway patients peptide peripheral positive possible potential present Proc production proliferation protective protein recent receptor recognized regulation rejection reported role Science selection sequence showed shown signaling specific stimulation studies suggest surface T-cell tion tissue tolerance tumor cells vaccine virus vitro vivo