Gaba in Autism and Related Disorders

Front Cover
Dirk M. Dhossche
Gulf Professional Publishing, Dec 21, 2005 - Medical - 512 pages
Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.

* Discusses the neuropathology of the GABA system in autism
* Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism
* Includes information on the shared genetic risk factors between autism and major mental disorders
* Foreword by Eugene Roberts
 

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Contents

Neuropathology Alterations of the GABAergic System
1
VII
14
Discussion
15
The Role of GABA in the Early Neuronal Development
27
GABA as a Developmental Signal
40
GABAergic Signaling in the Developing Cerebellum
63
Insights into GABA Functions in the Developing Cerebellum
95
GABAMediated Depolarization and Calcium Increases
101
Aim
252
Predicted Role of Secretin and Oxytocin in the Treatment
273
Background
279
Findings
292
Future Directions
302
Immunological Findings in Autism
317
Stereotypic Behaviors
343
A Potential Model of Autism
359

Role of GABA in the Mechanism of the Onset of Puberty
113
Interference of Glutamic Acid Decarboxylase in Puberty
119
A Rosetta Stone for Understanding the Molecular
131
II
160
III
167
Reelin Glycoprotein in Autism and Schizophrenia
179
Catatonia and GABA?
189
Catatonia in PraderWilli Syndrome
203
Alcohol GABA Receptors and Neurodevelopmental Disorders
217
Role of GABA
224
Effects of Secretin on Extracellular GABA and Other Amino Acid
239
Anatomy of a Mutant
383
173
414
175
423
182
437
184
447
360
448
375
454
The Reelin Signaling Pathway
460
445
465
Copyright

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