Heart Development, Volume 342

Front Cover
Richard P. Harvey, Nadia Rosenthal
Gulf Professional Publishing, 1999 - Medical - 530 pages
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The development of the cardiovascular system is an exciting and rapidly advancing area of biomedical research, powered by an urgent necessity to reduce the incidence of human cardiovascular disease. It is becoming increasingly clear that many of the congenital pathologies affecting the adult heart will be best understood by tracing their origins in embryonic development. The recent fusion of classical embryology with modern molecular genetics has resulted in an explosion of information about the developing heart in a variety of organisms. A comprehensive knowledge of the control circuitry in the cardiovascular system will form the basis for future advances in genetic therapy and organ culture. Heart Development presents a collection of chapters written by experts in the field, who describe their current insights into the molecular basis of cardiovascular development. The subject matter from the lineage origins and morphogenesis of the developing cardiovascular system, through genetic dissection of cardiovascular development in a variety of model organism, to the molecular basis of congenital heart defects. Its broad scope will appeal to the generalist or teacher seeking an overview of the subject, while also providing clinicians and medical researchers with comprehensive coverage of the most recent advances.
 

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Contents

Lineage
3
Patterning and Cell Commitment to
13
Cardiac Lineages
19
Origin of the Cardiac
26
Heart Formation and the Heart Field
37
VI
51
Genetic Determination of Drosophila
65
VI
66
Serum Response FactorNK
273
Ill Serum Response Factor
280
GATA Transcription Factors
291
GATA4 Activates Transcription via
297
Potential Functional Redundancy and Cross
301
Multiple Layers of Control
307
Nigel A Brown 447 The Childrens Hospital of Philadelphia and
333
AnteriorPosterior
344

A Combination of Inductive Signals
74
Specification of Cardiac Cell Types
82
Mutations Affecting Cardiac
93
Transcriptional Control and Pattern
111
VII
131
An Evolutionarily Conserved Pathway
139
Ill Molecular Segmentation
145
Relevance to Human Disease
153
Mechanisms of Segmentation
159
Developmental Fates of the JB3 Endocardial
168
Introduction
179
DORV and Red Herrings
187
Development of the Conduction
195
Perspectives
204
Molecular Mechanisms
221
Endothelial Proliferation
227
Vascular Pruning and Remodeling
237
Conclusion
244
Genetic Control of Muscle
253
Numbers in parentheses indicate the pages on which the School of Medicine Philadelphia Pennsylvania
255
Induction of MLC2v and MLC2a
267
ChamberSpecific Gene Expression
357
Role of the Midline
380
Conclusions
386
Gene Expression within
395
Development and Disease
403
xiii
405
Signal Transducers
409
Regulation of Vascular Smooth
429
Regulation of VSMC Apoptosis
436
Human Cardiac
445
Morphology of Hearts with Isomeric
453
The Genetic Basis of Conotruncal
463
Ill Development of Structures Affected
467
Identification of the Etiologic Genes
473
Genetics of Human LeftRight
479
Lessons from
491
Skeletal Muscle Development
498
Positional Information in Striated Muscle
507
Index
519
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About the author (1999)

Massachusetts General Hospital East

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