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Studies with Tetracycline Analogues
Resistance of Bacteria to the Tetracyclines
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30S ribosomal subunit 70S ribosomes Acad Acta actinomycin action of Sm action of streptomycin activity alanine amino acids anti antibacterial antibiotic Antibiotica assay aureus azaserine Bact bacteria bactericidal base pair binding of aminoacyl-tRNA binding of tetracycline Biochem Biol biophys carbomycin cell wall cell-free Chem chemical chromophore complex concentration culture cycloserine DNA synthesis doses drug effect enzyme erythromycin Escherichia coli ethambutol formation fusidic acid growth guanine hydrogen hypothesis incorporation infections inhibition inhibitory interaction isoniazid isonicotinic acid lincomycin mechanism of action messenger RNA metabolism Microbiol Miscoding mode of action molec molecular molecule mycin nalidixic acid novobiocin nucleic acid nucleotides observed oleandomycin penicillin peptide poly polysomes Proc protein biosynthesis protein synthesis purines puromycin pyrazinamide reaction replication resistance ribo ribonucleic acid ribosomes ristocetin sensitive specific spiramycin staphylococci strains streptomycin structure studies tetracycline to ribosomes therapy Toxic transfer RNA tRNA tuberculostatic ug/ml uptake vancomycin vitro vivo Wash