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Clinical Analgesic Studies and Sources of Variation in Analgesic
Clinical Implications of Morphine Plasma Levels in Advanced
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agonist analgesia analgesic analgesic effect Analgesic Studies approximately assay binding bioavailability blood bolus buprenorphine butorphanol C. E. Inturrisi cancer pain cancer patients catheter chronic pain clearance Clin clinical codeine compared DADL dose of morphine elimination enkephalins epidural estimate Foley and C. E. half-life hepatic heroin Houde hydromorphone injection intramuscular intramuscular morphine intrathecal intravenous Kaiko ketobemidone kinetics levorphanol liver lumbar mean plasma measured medication meperidine metabolism metabolites methadone metkephamid mg morphine nalbuphine nalorphine naloxone narcotic analgesics ng/ml normeperidine observed opiate oral dose oral morphine oxycodone p-endorphin pain intensity pain relief parenteral patients receiving patients with chronic peak pentazocine pethidine pharmacodynamic pharmacokinetic Pharmacol pharmacological placebo plasma concentration plasma levels plasma methadone postoperative pain potency ratio Raven Press relationship relative potency renal reported respiratory depression route of administration samples score side effects spinal sublingual systemic Table Ther therapy tolerance treatment Wallenstein Yaksh York