Progress in Hodgkin's DiseaseG. W. Richter, Kim Solez International Review of Experimental Pathology, Volume 33: Progress in Hodgkin's Disease summarizes the progress made in the diagnosis and understanding of the pathogenesis of Hodgkin's disease. The first half of this volume deals with diagnostic aspects, whereas the second half focuses on recent developments in the understanding of the pathogenesis of Hodgkin's disease. The book opens with a chapter on the differential diagnosis between Hodgkin's disease and non-Hodgkin's lymphomas, and provides guidelines on how to deal with the grey areas between these two groups of diseases. Separate chapters follow on the criteria for a prognostically relevant histological grading of the most common subtype of Hodgkin's disease; data on the nodular lymphocyte predominance subtype of Hodgkin's disease; and the various reagents used to define the immunophenotype of Reed-Sternberg cells. Subsequent chapters deal with potential mediators of lymphocyte agglutination to Reed-Sternberg cells; immunological alterations in Hodgkin's disease; molecular genetic studies into the pathogenesis of Hodgkin's disease; and results of studies on Hodgkin cell lines. This book provides data that go beyond those covered in textbooks in pathology and hematology and should be of interest to all pathologists and clinicians dealing with the diagnosis and management of Hodgkin's disease, as well as to lymphoma researchers. |
Contents
| 1 | |
A Study of 2190 Patients | 27 |
Chapter 3 LymphocytePredominance Hodgkins Disease | 53 |
Chapter 4 Immunophenotype of ReedSternberg Cells | 81 |
Chapter 5 The Nature and Function of the Hodgkins Cell Lectin and Its Role in Lymphocyte Agglutination | 115 |
Chapter 6 Role of T Cells in the Pathogenesis of Hodgkins Disease | 141 |
Common terms and phrases
activity aHBP-I ALCL antibody antigen biopsy Blood Cancer Philadelphia Cancer Res CD4+ cell receptor cell surface cells and variants chain gene rearrangements Clin clinical clonal cytes cytoplasmic Delsol demonstrated detected diagnosis Diehl differential diffuse eosinophils etal expression Falini follicular Gatter gene rearrangements germinal centers Grade 2 NS Hansmann HD patients hepatic hepatic receptor histiocytes histological Hodgkin’s cell lectin Hodgkin’s disease immune Immunol immunologic immunophenotype involved Kadin L&H cells L&H type lacunar large cell lymphoma Lennert Leu-Ml LPHD lymph nodes lymphocyte depletion lymphocytes lymphoid Maggi malignant membrane mitogen molecular monoclonal monocytes morphologic neoplastic NLPHD nodular sclerosis nodules Paietta paragranuloma pathogenesis Pathol patients with HD phenotype Pinkus polymerase chain reaction Poppema positive protein PTGC reactive receptor gene Reed—Sternberg cells Romagnani Schaadt Schwarting Southern blot staining Stein studies subtype TCCs TCR-B tissue tumor cells tumor-infiltrating type RS cells Vaughan Hudson virus Warnke Weiss X-hapten