Molecular Specialization and Symmetry in Membrane Function

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Arthur Kaskel Solomon, Manfred L. Karnovsky
Harvard University Press, 1978 - Science - 340 pages
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Biological membranes have been under intensive investigation for several decades. Despite very great experimental challenges, membranes are at last beginning to reveal their secrets. In this book, leading investigators of membrane structure and function report on progress in three related fields: specialization of membrane regions, asymmetry in transport properties, and differentiation of cell faces in epithelia.

"Specialization at the Molecular Level" is the subject of the first section; in it, the authors consider such problems as the biogenesis of membranes, the geometry of protein-lipid relationships, and the physical properties of membrane receptor-sites. In the second section, "Asymmetry in Transport," such topics as the sodium-potassium pump, proton translocation, and anion transport are covered. The last section is entitled "Polar Faces in Epithelia" and deals with the complex properties of ion transport across the complex membrane environment maintained by surfaces such as the renal tubular epithelia.

 

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Contents

Membrane Biogenesis
3
LipidProtein Associations
31
Molecular Architecture of Oligomeric Membrane Proteins
61
Transmembrane Compositional Asymmetry of Lipids
78
LigandBinding Properties of MembraneBound Choliner
99
The Functional Roles of Band 3 Protein of the Red Blood
128
Energetics and Molecular Biology of Membrane Transport
160
Asymmetry and the Mechanism of the Red Cell NaK
191
Proton Translocation in Submitochondrial Particles
222
Studies on the Molecular Mechanism of Anion Trans
229
The DoubleMembrane Model for Transepithelial
253
Differentiation of Cell Faces in Epithelia
272
SoluteCoupled Water Transport in the Kidney
294
Modes of Sodium Transport in the Kidney
316
Index
333
Copyright

Simultaneous or Consecutive Occupancy by Sodium
212

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