Epstein-Barr Virus and Associated Diseases: Proceedings of the First International Symposium on Epstein-Barr Virus-Associated Malignant Diseases (Loutraki, Greece—September 24–28, 1984)P.H. Levine It has been slightly more than two decades since the Epstein-Barr virus (EBV) was discovered by Prof. M.A. Epstein and his colleagues at the University of Bristol in their search for the causative agent of Burkitt's lymphoma. For several years EBV was a "virus in search of a disease." The first documentation that EBV was pathogenic for humans was in 1969 when Drs. Gertrude and Werner Henle identified it as the causative agent for infectious mononucleosis. Seroepidemiologic and biochemical studies subsequently linked EBV to Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), and more recently to the X-linked lymphoproliferative syndrome. With its widespread pattern of infection and a predilection for producing clinical signs and symptoms in only certain individuals, EBV has provided a model for many other candidate oncogenic viruses, including papilloma viruses, herpes simplex, and HTLV/LAV. In 1975, an international workshop was sponsored by the National Cancer Institute to address the problem of EBV production, thus facilitating basic research on the virus. This proved to be the last international meeting on EBV for almost a decade. In the past, progress in both clinical and basic research on EBV has been presented in two types of international meetings, the international herpesvirus workshops devoted primarily to basic research on both human and animal herpesviruses, and the international symposia on NPC, in which EBV-related studies were interspersed with clinical, epidemiologic and other etiologic aspects of this important human neoplasm. |
Contents
Association of EpsteinBarr Virus and Lymphoproliferative | 3 |
Relapsing Recurrent and Chronic Infectious Mononucleosis | 18 |
Immune Assessment of Patients with Chronic Active EBV | 34 |
Copyright | |
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Epstein-Barr Virus and Associated Diseases P H Levine,D V Ablashi,G R Pearson No preview available - 1985 |
Common terms and phrases
Acad acid activity Acyclovir ADCC antigen assay associated B-lymphocytes BamHI biopsy Burkitt's lymphoma c-myc Cancer cell lines cellular chromatin chromosome clinical cloned culture cytotoxicity detected disease early antigen EB virus EBNA EBV DNA EBV genome EBV infection EBV-associated EBV-specific EcoRI encoded epithelial cells Epstein Epstein-Barr virus DNA Epstein-Barr virus EBV expression fragment gene genetic genome Glaser GLY ALA GLY glycoprotein Henle human hybridization IgA/VCA immune deficiency immunoblotting immunofluorescence immunoglobulin Immunol induced infectious mononucleosis Kieff Klein lymphoblastoid lymphoblastoid cell lines lymphocytes malignant membrane antigen monoclonal antibodies Namalwa nasopharyngeal carcinoma Natl nitrocellulose normal NPC patients nuclear antigen Pearson peptide polypeptide positive Proc protein purified Purtilo Raji cells reading frame region replication response sequence sera serologic serum specific studies suppressor suppressor cells syndrome T-cell Table tissue titers transfected transformation tumor viral genome virions Virol vitro